Debunking a racialist myth about the genetic variation between dog breeds

In a previous entry, I made the following comment:

For dogs it’s:

Canus (genus) lupus (species) familiaris (subspecies).

There are 37 subspecies of Canis lupus.

Breeds don’t qualify as subspecies.  The genetic differentiation between dog breeds is tiny (don’t know exact percentage, but it’s much less than between human races).

This is not true. 

I’ve heard this bit about limited genetic differentiation in dogs repeated a number of times in racialist circles.  I remember Jared Taylor using it in a debate with Tim Wise. 

Steve Sailer wrote:

Dog genome research progress has been fairly slow, partly for economic reasons, but partly, I suspect, because dogs aren’t really that variable, strange as it may seem. Without breeding, dogs in the tropics seem to wind up medium size, short-haired, and yellowish, reddish, or brownish.

My hunch is that genetic diversity in dogs will prove to be narrow but deep, focusing on a small number of genes that vary sharply, whereas genetic diversity among humans will prove broader but shallower than among dogs, involving more genes than among dog breeds, but not as sharply defined. [ed- this last part might be true- there may be fewer SNPs in dogs, but I’m not sure about this.  It is certainly true that indivisual SNPs have much larger phenotypic effects in dogs, which is one reason why a comparison between dog breeds and human races could be considered inappropriate]

The myth seems to originate from the book Race: The Reality of Human Differences, by Frank Miele and Vincent Sarich (which I also read several years ago).  Miele writes:

I (Miele) then raised the question of dog breeds. I’ve liked dogs since I was a kid and am now on my third (the first two bullterriers and now a Great Dane).  I’ve also been to a number of dog shows and even took my first bull terrier to an AKC championship.  In addition, I’ve read widely both in the popular literature on dogs as well as in scientific journals that cover canine behavior genetics.  I pointed out to Vince that there were huge differences between dog breeds, both in morphology and in behavior.  How different were they genetically?  Had the same methodology been applied to sorting out dog breeds as was described for humans in Chapter 5?  With such large morhphological and behavioral differences, shouldn’t there be large DNA differences betwen the breeds? (It is now well known that the morphological and behavioral characteristics that distinguish breeds from one another are genetically bases.)  Vince’s surprising answer was that (at that time) not only were there no known DNA differences between the breeds, but these methods couldn’t even distinguish between domestic dogs and wolves.  Although it was possbile to identify individuals with the same microsatellite approach that has been in use for the past two decades, only this year (2003) have researchers been able to distinguish between a few dog breeds by DNA differences.

Miele also repeated parts of this in an online essay published on Vdare in 2008:

Despite minimal genetic differences,  human physical racial differences are clearly observable.

Likewise for dogs. But only recently has genetic analysis been able to distinguish between breeds—or even between dogs and wolves.

Vince’s surprising answer, though, was very misleading.  Or Miele misinterpreted what he was told.

In reality, dog breeds are much more genetically diverse than human races, and they can be classified very accurately.

In a 2004 paper in Science, Parker et al. showed that very accurate classification is possible (410 of 414 dogs were correctly assigned to their breed).  They also showed by Analysis of Molecular Variance (AMOVA, a technique often used for estimating genetic variability using microsattelites and repeats, although it can also be used for SNPs) that 27% of genetic variance is between breeds.  Using SNP data, they calculated an Fst distance between the breeds of 0.33.  A recent paper on a genome-wide SNP analysis on 919 dogs from 85 breeds, showed by AMOVA that 65.1% of genetic variance was within breeds, 31.1% between breeds, and 3.8% between breed groups (they defined 10 different groups:  Spaniels, Retrievers, etc.).  They also that as few as 20 diagnostic SNPs can be used to accurately classify dogs into their breeds.

How does the genetic variation in dogs compare to that of humans?  AMOVA analysis of humans shows that approximately 85% of variance is between individuals, 5% is between populations in the same racial group, and 10% is interracial (btw, this number is also close to the updated Fst measurement of Xing et al.).  The average Fst distance between human races is approximately 0.15.

So, we can see that dog breeds are actually much more variable than human races.  The myth of limited genetic diversity prevalent in racialist circles (to which I also fell victim) needs to be dispelled.

 

 

Posted by Dasein on Wednesday, July 28, 2010 at 10:29 AM in Genetics & Human Bio-Diversity
Comments (14) | Tell a friend

Comments:

1

Posted by seawolf on July 28, 2010, 10:58 PM | #

It’s gene expression!  Look for the epigenetic factors between races.

The human genome has not even been sequenced, with many stretches still unread.  And then there is the epigenetic factors which control when, how much, and the quality of the expression.  We haven’t even scratched the surface of genetics, so in the meantime, I’ll use my visual and empirical experiences to judge racial differences.

Do you still stand by your prior post (Venter) in which you mention a 98.4% relatedness between randomly chosen humans considering SNPS, indels, and CNV (i.e., on par with 98.5%  chimp/human differences) ?

2

Posted by Dasein on July 29, 2010, 05:17 AM | #

Yes, of course I stand by that post.  That is the best current estimate we have.  Do you know of another?

The last I heard, the estimate of chimp/human similiarity was ~96%, and this will certainly go down again when chimp and human genomes sequenced at the level of detail in that Pang paper are compared.  And if and when sequencing technology permits the complete sequencing of those regions that are currently problematic, this will go down even further.

3

Posted by asdf on July 29, 2010, 08:53 AM | #

Dasein,

You appear to be fixated on Lewontin’s fallacy, and unable to move on. Otherwise I cannot explain your reducing everything to it.

4

Posted by Dasein on July 29, 2010, 09:27 AM | #

No, I’m debunking a myth prevalent in racialist circles.

5

Posted by asdf on July 29, 2010, 10:26 AM | #

Dog breeds are not by any means “much more genetically diverse than human races,” and that does not follow from within≬apportionment of variance or such meaningless statistical drivel.

6

Posted by Dasein on July 29, 2010, 01:29 PM | #

Is your objection to the use of “much,” or Fst and AMOVA?  Do you think those measures are completely meaningless?  Let’s see the papers showing human races have more genetic variation than dog breeds.

7

Posted by FB on July 29, 2010, 09:07 PM | #

Is Dasein channelling Tim Wise? Now that he has debunked that racist myth, it’s important for him not to rest on his laurels! What a nut.

8

Posted by seawolf on July 29, 2010, 11:46 PM | #

Dasein,

Thanks for your posts.  We learn a lot from them.

FB,

Lighten up!

9

Posted by Dasein on July 30, 2010, 12:19 AM | #

Thank you, Seawolf.

10

Posted by asdf on July 30, 2010, 06:03 PM | #

Is there any way to PM here, or for GW to give you my mail addy?

11

Posted by Guessedworker on July 30, 2010, 06:36 PM | #

Send your mail for my attention through the contact button and I will pass it on.

12

Posted by alex zeka on July 30, 2010, 07:00 PM | #

So, in dogs the variation is 35% (31.1+3.8) and in humans its just under half that (15%=10%+5%). Whilst this is of course crude and some gene variations matter more than others, etc. but that does mean that the difference between a white and a black is just under half that between a bulldog and a chihuahua. Which basically in layman’s speak is fuckin’ huge.

Thanks to Dasein for pointing out the error, especially as the revised version is still a powerful race realist argument.

13

Posted by Dasein on August 10, 2010, 08:38 AM | #

asdf,

You’re right- I’ve conflated genetic variance and genetic diversity.  There seems to be confusion in the literature on this as well.  For example, Holsinger and Weir, in a recent NRG review stated that:

For example, recent analyses based on more than 370 short tandem repeat loci1 (microsatellites) and 600,000 SNPs2 suggest that only 5–10% of human genetic diversity is accounted for by genetic differences among populations from major geographical regions. These results indicate that there are far more similarities among geographically distinct human populations than differences. But what does it mean to say that 5–10% of diversity is accounted for by differences among populations, and how is this figure derived? The short answer is that the estimate of FST among human populations sampled from these regions is 0.05 for the microsatellite data and 0.10 for the SNP data.

The Wikipedia entry for human genetic variation also conflates the terms:

Human genetic variation is the genetic diversity of humans and represents the total amount of genetic characteristics observed within the human species.

I’m not sure exactly how AMOVA is calculated, but for Fst it seems genetic variability might be a more appropriate term for what it’s measuring.  Or genetic differentiation, which is another thing Holsinger and Weir say it measures.  I know Jost has been critical of Fst, saying that it is not a true measure of genetic differentiation.  Whether it’s the best measure or not is perhaps not so important for the point I’m trying to make here, though, which is that, by published accounts, dog breeds are more differentiated than are human races.  And, according to commonly-used measures in population genetics, there is more genetic variation between dog breeds than between human races.  I think those are fair statements, even if there’s some debate as to whether Fst and AMOVA are appropriate measures of these things.

14

Posted by gagoonies on October 12, 2010, 03:53 PM | #

I understand & agree with what you are attempting to communicate.

Race is real. It is a biological extension of family, those expressing traits.

Some are so lowly & enslaved by the dogmatic lies of their sickly churches. That they feel the need to lie. They feel the need to deny all truths which do not agree with their views. In order to make themselves feel good about their ugly behavior they deny the plain to see existence of race. These creatures are waging open genocide daily against whites.

Destabilizing the nations we build. They seek to destroy the biodiversity of man. That we all might be as ugly as they. Their twisted biased minds cry that race does not exist because their desires demand it. Their desires are based on selfish greed & wishful thinking.

The reason they behave in such terrible ways. Is because they know ultimately they are defeated. They sense how alien we are to them.

It has nothing to do with governments. It has everything to do with the individual walking through the street. That is where the untelevised revolution takes place daily. Will you upon being confronted by a foe fall away in fear of your attacker or will you stand your ground to fight for what is yours.

The negro should be expelled from all our territories. It is selfish of our generations not to do the work that must be done to preserve our legacy. Our apathy is destroying our world. We must act to defend ourselves. Our governments obviously no longer have our populations best interests in heart. They give away what countless lives such as ours were sacrificed ritually for. They give away our futures.

All you must do is live life to its fullest to defeat them. The muggles want you to cower in fear of them. They dont want you shopping in the stores, walking down the streets, and playing in the parks they use. They want you away from them. They want control.  Wrestle it from them. Compete with them.

Get right up in their ugly faces & explain away all the lies which support their existence. To humor their propaganda is to stab oneself in the heart to cease its beating. May your heart beat vibrantly. Should you find yourself grabbed by these beasts, then turn & grab them back. Go bump in night. Let them know they don’t call the shots, compete with them. That these traits of race might continue to exist in the future.

When you fight them. Do so to kill. Their acts of defiance should never be tolerated.

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