The Pentagon has yet to report on the cost of President Trump’s Iran adventure, but a brief summation of aircraft losses and damage was made available a week ago by CRS.  Its report covers losses and damage to friendly fire and accident as well as enemy action.  It has to be said that the list is not encouraging for the American military, and one may suppose that the longer-term will see the development of alternatives where possible to crewed operations.  Replacement of the costly, vulnerable and outdated Reaper is already under discussion.  More generally, Bloomberg has reported that the US Department of Defense has asked to test a range of Ukrainian defense products, including drones and electronic warfare systems with a view to the transfer of technology and access to intellectual property rights.

The CRS list is:

Four F-15E Strike Eagle fighter aircraft

On March 2, 2026, CENTCOM reported that three F-15Es were shot down and destroyed by friendly fire over Kuwait; all six aircrew ejected safely and were recovered.
On April 5, 2026, CENTCOM reported that one F-15E was shot down and destroyed during combat operations over Iran; both aircrew were safely recovered during separate search-and-rescue operations.
One F-35A Lightning II fighter aircraft

A March 19, 2026, news article reported that Iranian ground fire damaged one F-35A during combat operations over Iran.
One A-10 Thunderbolt II ground-attack aircraft

In an April 6, 2026, news conference, Chairman of the Joint Chiefs of Staff Air Force General Dan Caine stated that on April 3, enemy fire struck one A-10 that subsequently crashed and was destroyed during search-and-rescue operations; the pilot ejected and was recovered safely.
Seven KC-135 Stratotanker aerial refueling aircraft

On March 12, 2026, CENTCOM reported that two KC-135s were involved in an incident over friendly airspace; one aircraft crashed in Iraq, resulting in the deaths of all six aircrew. The second KC-135 made an emergency landing at an undisclosed location in the region where U.S. forces are hosted.
A March 14, 2026, news article reported that five KC-135s were damaged while on the ground at Prince Sultan Air Base, Saudi Arabia, during an Iranian missile and drone attack.
One E-3 Sentry airborne early warning-and-control system aircraft (AWACS)

A March 28, 2026, news article reported that one E-3 was struck and damaged while on the ground at Prince Sultan Air Base, Saudi Arabia, during an Iranian missile and drone attack. A May 7, 2026, news article reported that the E-3 had been parked on an unprotected taxiway.
Two MC-130J Commando II special operations aircraft

An April 5, 2026, news article reported that two MC-130Js supporting search-and-rescue operations for a downed F-15E were intentionally destroyed on the ground in Iran after becoming unable to depart; all aircrew were safely evacuated.
One HH-60W Jolly Green II combat search-and-rescue helicopter

On April 6, 2026, General Caine said in a press conference that on April 5, one HH-60W sustained damage from small-arms fire supporting search-and-rescue operations for a downed F-15E in Iran.
Twenty-four MQ-9 Reaper medium-altitude long-endurance uncrewed aircraft

An April 9, 2026, news article reported that the U.S. military had lost 24 MQ-9 Reapers since the start of U.S. military operations against Iran.
One MQ-4C Triton high-altitude long-endurance uncrewed aircraft

An April 14, 2026, news article citing a U.S. Navy document reported that one MQ-4C crashed in a mishap.